This study evaluated the diagnostic accuracy of an artificial intelligence (AI) algorithm for predicting Helicobacter pylori infection using endoscopic images, given the absence of established optical diagnosis methods. A meta-analysis of 8 studies showed that AI had a pooled sensitivity of 87%, specificity of 86%, and an area under the curve of 0.92 for detecting H. pylori infection. The AI algorithm demonstrated reliable performance, although further external validation and broader geographical testing are needed to address limitations.