High-risk molecular markers play a key role in glioma grading, survival, and prognosis, but current genetic testing methods are invasive and time-consuming. Advanced magnetic resonance imaging (MRI) offers a non-invasive alternative that may reflect pathological features associated with these markers, although it struggles with glioma heterogeneity. This study explores Artificial intelligence (AI) imaging, which has emerged as an efficient non-invasive method for identifying high-risk molecular markers in gliomas, with ongoing research addressing its potential and challenges.