A deep learning model, Lymphoma Artificial Reader System (LARS), was developed to classify [18F]FDG-PET-CT scans of lymphoma patients based on the presence of hypermetabolic tumor sites. Trained on over 16,000 scans, LARS demonstrated high accuracy, sensitivity, and specificity in both internal and external test cohorts. This model has the potential to assist imaging specialists in managing large scan volumes by accurately identifying metabolically active disease, potentially serving as a second reader or decision support tool.